Estoy ejecutando AQTime en esta parte del código, descubrí que .IndexOf toma el 16% del tiempo frente a cerca del 80% para la otra parte ... Parece que usan el mismo IsEqual y otras rutinas. Llamado 116,000 veces insertando 30,000 artículos. Ninguno de los objetos Lista <> obtiene más de 200 elementos. (Puedo estar usando AQTime incorrectamente, estoy investigando esto)

class PointD : IEquatable<PointD>
{
    public double X, Y, Z;

    bool IEquatable<PointD>.Equals(PointD other)
    {
        return ((X == other.X) && (Y == other.Y) && (Z == other.Z));
    }
}

class PerfTest
{
    readonly List<PointD> _pCoord3Points = new List<PointD>();
    public int NewPoints;
    public int TotalPoints;

    public PerfTest()
    {
        NewPoints = 0;
        TotalPoints = 0;
    }
    public int CheckPointIndexOf(PointD pt)
    {
        int retIndex = _pCoord3Points.IndexOf(pt);
        if (retIndex < 0)
        {
            _pCoord3Points.Add(pt);
            NewPoints++;
        }
        TotalPoints++;
        return retIndex;    
    }

    public int CheckPointForBreak(PointD pt)
    {
        int retIndex = -1;
        for (int i = 0; i < _pCoord3Points.Count; i++)
        {
            PointD otherPt = _pCoord3Points[i];
            if ((pt.X == otherPt.X) &&
                (pt.Y == otherPt.Y) &&
                (pt.Z == otherPt.Z))
            {
                retIndex = i;
                break;
            }
        }
        if (retIndex == -1)
        {
            NewPoints++;
            _pCoord3Points.Add(pt);
        }
        TotalPoints++;
        return retIndex;
    }

    static void Main()
    {
        const int xmax = 300;
        const int ymax = 10;
        const int zmax = 10;
        const int imax = 4;

        var test = new PerfTest();
        //test.Init();
        Stopwatch sw = Stopwatch.StartNew();
        for (int i = 0; i < imax; i++)
        {
            for (int x = 0; x < xmax; x++)
            {
                for (int y = 0; y < ymax; y++)
                {
                    for (int z = 0; z < zmax; z++)
                    {
                        var pt = new PointD { X = x, Y = y, Z = z };
                        test.CheckPointIndexOf(pt);
                    }
                }
            }

        } 
        sw.Stop();
        string output = string.Format("Total: {0:0} New: {1:0} IndexOf: ", test.TotalPoints, test.NewPoints);
        Console.Write(output);
        Console.WriteLine(sw.Elapsed);

        test = new PerfTest();
        sw = Stopwatch.StartNew();
        for (int i = 0; i < imax; i++)
        {
            for (int x = 0; x < xmax; x++)
            {
                for (int y = 0; y < ymax; y++)
                {
                    for (int z = 0; z < zmax; z++)
                    {
                        var pt = new PointD { X = x, Y = y, Z = z };
                        test.CheckPointForBreak(pt);
                    }
                }
            }

        } 
        sw.Stop();
        output = string.Format("Total: {0:0} New: {1:0} PointD[] ", test.TotalPoints, test.NewPoints);
        Console.Write(output);
        Console.WriteLine(sw.Elapsed);
        Console.ReadLine();
    }
}