Eu tenho um problema com isso ?! Eu uso dessa maneira para executar apenas uma instância do programa. faz muito bom.mas quando eu uso dessa maneira em outro aplicativo. Quando eu corro um deles programas através de um atalho do desktop, ambos os programas invocam e mostram na área de trabalho. nota: ambos os programas são executados no sistema Windows.

    static bool ok;
    static Mutex mutex = new Mutex(true, "{123Newsoft-Cleaner Portable Program123}",out ok);

    /// <summary>
    /// The main entry point for the application.
    /// </summary>
    [STAThread]

    static void Main()
    {
        //Application.EnableVisualStyles();
        //Application.SetCompatibleTextRenderingDefault(false);
        //Application.Run(new Form1());

        if (mutex.WaitOne(TimeSpan.Zero, true))  
        {

            Application.EnableVisualStyles();
            Application.SetCompatibleTextRenderingDefault(false);


            var mainForm = new Form1c();

            try
            {                                    

                    mainForm.Visible = false;


                    mainForm.WindowState = FormWindowState.Normal;                  

            }
            catch (Exception ex)
            {
                MessageBox.Show(ex.Message, "error", MessageBoxButtons.OK, MessageBoxIcon.Error);
            }

            Application.Run(mainForm);               

        }
        else
        {

            NativeMethods.PostMessage((IntPtr)NativeMethods.HWND_BROADCAST, NativeMethods.WM_SHOWME, IntPtr.Zero, IntPtr.Zero);

        }

// ---------------- na forma principal

    protected override void WndProc(ref Message M_C)
    {

        if (M_C.Msg == NativeMethods.WM_SHOWME)
        {               
            ShowMe();
        }
        base.WndProc(ref M_C);
    }

    //*************
    private void ShowMe()
    {

        if (WindowState == FormWindowState.Minimized)
        {
            Show();
            WindowState = FormWindowState.Normal;
        }

        // get our current "TopMost" value (ours will always be false though)
        bool top = TopMost;
        // make our form jump to the top of everything
        TopMost = true;
        // set it back to whatever it was
        TopMost = top;

    }